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Modulation of Integrin Activation by an Entropic Spring in the β-Knee
We show that the length of a loop in the β-knee, between the first and second cysteines (C1-C2) in integrin EGF-like (I-EGF) domain 2, modulates integrin activation. Three independent sets of mutants, including swaps among different integrin β-subunits, show that C1-C2 loop lengths of 12 and longer...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2963379/ https://ncbi.nlm.nih.gov/pubmed/20670939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.145177 |
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