Modulation of Integrin Activation by an Entropic Spring in the β-Knee

We show that the length of a loop in the β-knee, between the first and second cysteines (C1-C2) in integrin EGF-like (I-EGF) domain 2, modulates integrin activation. Three independent sets of mutants, including swaps among different integrin β-subunits, show that C1-C2 loop lengths of 12 and longer...

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Autors principals: Smagghe, Benoit J., Huang, Po-Ssu, Ban, Yih-En Andrew, Baker, David, Springer, Timothy A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963379/
https://ncbi.nlm.nih.gov/pubmed/20670939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.145177
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