Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model

Plasmodium falciparum, the causative agent of the most deadly form of human malaria, is unable to salvage pyrimidines and must rely on de novo biosynthesis for survival. Dihydroorotate dehydrogenase (DHODH) catalyzes the rate-limiting step in the pyrimidine biosynthetic pathway and represents a pote...

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Main Authors: Booker, Michael L., Bastos, Cecilia M., Kramer, Martin L., Barker, Robert H., Skerlj, Renato, Sidhu, Amar Bir, Deng, Xiaoyi, Celatka, Cassandra, Cortese, Joseph F., Guerrero Bravo, Jose E., Crespo Llado, Keila N., Serrano, Adelfa E., Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Viera, Sara, Garuti, Helen, Wittlin, Sergio, Papastogiannidis, Petros, Lin, Jing-wen, Janse, Chris J., Khan, Shahid M., Duraisingh, Manoj, Coleman, Bradley, Goldsmith, Elizabeth J., Phillips, Margaret A., Munoz, Benito, Wirth, Dyann F., Klinger, Jeffrey D., Wiegand, Roger, Sybertz, Edmund
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963363/
https://ncbi.nlm.nih.gov/pubmed/20702404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.162081
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