m-calpain Activation Is Regulated by Its Membrane Localization and by Its Binding to Phosphatidylinositol 4,5-Bisphosphate

m-calpain plays a critical role in cell migration enabling rear de-adhesion of adherent cells by cleaving structural components of the adhesion plaques. Growth factors and chemokines regulate keratinocyte, fibroblast, and endothelial cell migration by modulating m-calpain activity. Growth factor rec...

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Autors principals: Leloup, Ludovic, Shao, Hanshuang, Bae, Yong Ho, Deasy, Bridget, Stolz, Donna, Roy, Partha, Wells, Alan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963356/
https://ncbi.nlm.nih.gov/pubmed/20729206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.123604
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