Isoform-specific Inhibition of TRPC4 Channel by Phosphatidylinositol 4,5-Bisphosphate

Full-length transient receptor potential (TRP) cation channel TRPC4α and shorter TRPC4β lacking 84 amino acids in the cytosolic C terminus are expressed in smooth muscle and endothelial cells where they regulate membrane potential and Ca(2+) influx. In common with other “classical” TRPCs, TRPC4 is a...

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Autores principales: Otsuguro, Ken-ichi, Tang, Jisen, Tang, Yufang, Xiao, Rui, Freichel, Marc, Tsvilovskyy, Volodymyr, Ito, Shigeo, Flockerzi, Veit, Zhu, Michael X., Zholos, Alexander V.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
Mechanisms of Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2365920/
https://ncbi.nlm.nih.gov/pubmed/18230622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707306200
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