The Pseudo Signal Peptide of the Corticotropin-releasing Factor Receptor Type 2a Decreases Receptor Expression and Prevents G(i)-mediated Inhibition of Adenylyl Cyclase Activity

The corticotropin-releasing factor receptor type 2a (CRF(2(a))R) belongs to the family of G protein-coupled receptors. The receptor possesses an N-terminal pseudo signal peptide that is unable to mediate targeting of the nascent chain to the endoplasmic reticulum membrane during early receptor bioge...

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Detalhes bibliográficos
Main Authors: Schulz, Katharina, Rutz, Claudia, Westendorf, Carolin, Ridelis, Ingrid, Vogelbein, Susanne, Furkert, Jens, Schmidt, Antje, Wiesner, Burkhard, Schülein, Ralf
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963340/
https://ncbi.nlm.nih.gov/pubmed/20682782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.129627
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