The signal peptide of the rat corticotropin-releasing factor receptor 1 promotes receptor expression but is not essential for establishing a functional receptor

Approximately 5–10% of the GPCRs (G-protein-coupled receptors) contain N-terminal signal peptides that are cleaved off during receptor insertion into the ER (endoplasmic reticulum) membrane by the signal peptidases of the ER. The reason as to why only a subset of GPCRs requires these additional sign...

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Bibliographic Details
Main Authors: Alken, Martina, Rutz, Claudia, Köchl, Robert, Donalies, Ute, Oueslati, Morad, Furkert, Jens, Wietfeld, Doreen, Hermosilla, Ricardo, Scholz, Anne, Beyermann, Michael, Rosenthal, Walter, Schülein, Ralf
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2005
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1198925/
https://ncbi.nlm.nih.gov/pubmed/15901239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20050113
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