GSK1562590, a slowly dissociating urotensin-II receptor antagonist, exhibits prolonged pharmacodynamic activity ex vivo

BACKGROUND AND PURPOSE: Recently identified antagonists of the urotensin–II (U-II) receptor (UT) are of limited utility for investigating the (patho)physiological role of U-II due to poor potency and limited selectivity and/or intrinsic activity. EXPERIMENTAL APPROACH: The pharmacological properties...

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Autors principals: Behm, DJ, Aiyar, NV, Olzinski, AR, McAtee, JJ, Hilfiker, MA, Dodson, JW, Dowdell, SE, Wang, GZ, Goodman, KB, Sehon, CA, Harpel, MR, Willette, RN, Neeb, MJ, Leach, CA, Douglas, SA
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2010
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962828/
https://ncbi.nlm.nih.gov/pubmed/20718751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00889.x
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