Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues

BACKGROUND AND PURPOSE: The recent development of the UT ligand palosuran (1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea sulphate salt) has led to the proposition that urotensin-II (U-II) plays a significant pathological role in acute and chronic renal injury in the...

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Detalhes bibliográficos
Main Authors: Behm, D J, McAtee, J J, Dodson, J W, Neeb, M J, Fries, H E, Evans, C A, Hernandez, R R, Hoffman, K D, Harrison, S M, Lai, J M, Wu, C, Aiyar, N V, Ohlstein, E H, Douglas, S A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567886/
https://ncbi.nlm.nih.gov/pubmed/18587423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.266
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