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Inhibition of pathologic immunoglobulin free light chain production by small interfering RNA molecules

OBJECTIVES: Morbidity and mortality occurring in patients with multiple myeloma, AL amyloidosis, and light chain deposition disease can result from the pathologic deposition of monoclonal Ig light chains (LCs) in kidneys and other organs. To reduce synthesis of such components, therapy for these dis...

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Detalhes bibliográficos
Main Authors: Phipps, Jonathan E., Kestler, Daniel P., Foster, James S., Kennel, Stephen J., Donnell, Robert, Weiss, Deborah T., Solomon, Alan, Wall, Jonathan S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962681/
https://ncbi.nlm.nih.gov/pubmed/20637260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2010.07.001
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