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Aging of Xenopus tropicalis Eggs Leads to Deadenylation of a Specific Set of Maternal mRNAs and Loss of Developmental Potential

As first shown more than 100 years ago, fertilization of an aged (overripe) egg increases the rate of malformations and embryonic loss in several vertebrates, including possibly humans as well. Since the molecular events in aging eggs may be similar in these species, we established in the frog Xenop...

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Autors principals: Kosubek, Anna, Klein-Hitpass, Ludger, Rademacher, Katrin, Horsthemke, Bernhard, Ryffel, Gerhart U.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962626/
https://ncbi.nlm.nih.gov/pubmed/21042572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013532
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