Cot/tpl2 (MAP3K8) Mediates Myeloperoxidase Activity and Hypernociception following Peripheral Inflammation

Cot/tpl2 (also known as MAP3K8) has emerged as a new and potentially interesting therapeutic anti-inflammatory target. Here, we report the first study of Cot/tpl2 involvement in acute peripheral inflammation in vivo. Six hours after an intraplantar injection of zymosan, Cot/tpl2(−/−) mice showed a 4...

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Autori principali: Soria-Castro, Irene, Krzyzanowska, Agnieszka, Pelaéz, Marta López, Regadera, Javier, Ferrer, Gema, Montoliu, Lluis, Rodríguez-Ramos, Rosario, Fernández, Margarita, Alemany, Susana
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962480/
https://ncbi.nlm.nih.gov/pubmed/20736176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.169409
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