Differential effects of metalloporphyrins on messenger RNA levels of delta-aminolevulinate synthase and heme oxygenase. Studies in cultured chick embryo liver cells.

The acute porphyrias in relapse are commonly treated with intravenous heme infusion to decrease the activity of delta-aminolevulinic acid synthase, normally the rate-controlling enzyme in heme biosynthesis. The biochemical effects of heme treatment are short-lived, probably due in part to heme-media...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Cable, E E, Pepe, J A, Karamitsios, N C, Lambrecht, R W, Bonkovsky, H L
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1994
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296142/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8040318/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117381
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