Mechanism of Action and Antiviral Activity of Benzimidazole-Based Allosteric Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase

The RNA-dependent RNA polymerase of hepatitis C virus (HCV) is the catalytic subunit of the viral RNA amplification machinery and is an appealing target for the development of new therapeutic agents against HCV infection. Nonnucleoside inhibitors based on a benzimidazole scaffold have been recently...

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Autors principals: Tomei, Licia, Altamura, Sergio, Bartholomew, Linda, Biroccio, Antonino, Ceccacci, Alessandra, Pacini, Laura, Narjes, Frank, Gennari, Nadia, Bisbocci, Monica, Incitti, Ilario, Orsatti, Laura, Harper, Steven, Stansfield, Ian, Rowley, Michael, De Francesco, Raffaele, Migliaccio, Giovanni
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC296079/
https://ncbi.nlm.nih.gov/pubmed/14645579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.24.13225-13231.2003
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