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Oligomerization and Cooperative RNA Synthesis Activity of Hepatitis C Virus RNA-Dependent RNA Polymerase

The NS5B RNA-dependent RNA polymerase encoded by hepatitis C virus (HCV) plays a key role in viral replication. Reported here is evidence that HCV NS5B polymerase acts as a functional oligomer. Oligomerization of HCV NS5B protein was demonstrated by gel filtration, chemical cross-linking, temperatur...

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Publicado no:J Virol
Principais autores: Wang, Q. May, Hockman, Michelle A., Staschke, Kirk, Johnson, Robert B., Case, Katharine A., Lu, Jirong, Parsons, Steve, Zhang, Faming, Rathnachalam, Radhakrishnan, Kirkegaard, Karla, Colacino, Joseph M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2002
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136118/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11907226/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.8.3865-3872.2002
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