Mechanism of Action and Antiviral Activity of Benzimidazole-Based Allosteric Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase

The RNA-dependent RNA polymerase of hepatitis C virus (HCV) is the catalytic subunit of the viral RNA amplification machinery and is an appealing target for the development of new therapeutic agents against HCV infection. Nonnucleoside inhibitors based on a benzimidazole scaffold have been recently...

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Autores principales: Tomei, Licia, Altamura, Sergio, Bartholomew, Linda, Biroccio, Antonino, Ceccacci, Alessandra, Pacini, Laura, Narjes, Frank, Gennari, Nadia, Bisbocci, Monica, Incitti, Ilario, Orsatti, Laura, Harper, Steven, Stansfield, Ian, Rowley, Michael, De Francesco, Raffaele, Migliaccio, Giovanni
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC296079/
https://ncbi.nlm.nih.gov/pubmed/14645579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.24.13225-13231.2003
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