Evidence for failure of V(D)J recombination in bone marrow pre-B cells from X-linked agammaglobulinemia.
X-linked agammaglobulinemia (XLA) results from a failure of B lymphoid development. We have previously examined pre-B cell hybrids from three patients with XLA and found them to be limited to production of a novel germ line transcript of the Ig H chain locus composed of a leader sequence (LS) splice...
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| Vydáno v: | J Clin Invest |
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| Hlavní autor: | |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Clinical Investigation
1992
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295922/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1602011/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115817 |
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