Evidence for failure of V(D)J recombination in bone marrow pre-B cells from X-linked agammaglobulinemia.
X-linked agammaglobulinemia (XLA) results from a failure of B lymphoid development. We have previously examined pre-B cell hybrids from three patients with XLA and found them to be limited to production of a novel germ line transcript of the Ig H chain locus composed of a leader sequence (LS) splice...
সংরক্ষণ করুন:
| প্রকাশিত: | J Clin Invest |
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| প্রধান লেখক: | |
| বিন্যাস: | Artigo |
| ভাষা: | Inglês |
| প্রকাশিত: |
American Society for Clinical Investigation
1992
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295922/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1602011/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115817 |
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