S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis)

BACKGROUND: S110 is a novel dinucleoside analog that could have advantages over existing DNA methyltransferase (DNMT) inhibitors such as decitabine. A potential therapeutic role for S110 is to increase fetal hemoglobin (HbF) levels to treat β-hemoglobinopathies. In these experiments the effect of S1...

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Autors principals: Lavelle, Donald, Saunthararajah, Yogen, Vaitkus, Kestis, Singh, Mahipal, Banzon, Virryan, Phiasivongsva, Pasit, Redkar, Sanjeev, Kanekal, Sarath, Bearss, David, Shi, Chongtie, Inloes, Roger, DeSimone, Joseph
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958909/
https://ncbi.nlm.nih.gov/pubmed/20932295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-8-92
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