Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin

BACKGROUND AND PURPOSE: Carboxylesterases (CEs) metabolize a wide range of xenobiotic substrates including heroin, cocaine, meperidine and the anticancer agent CPT-11. In this study, we have purified to homogeneity human liver and intestinal CEs and compared their ability with hydrolyse heroin, coca...

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Detalhes bibliográficos
Main Authors: Hatfield, MJ, Tsurkan, L, Hyatt, JL, Yu, X, Edwards, CC, Hicks, LD, Wadkins, RM, Potter, PM
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958638/
https://ncbi.nlm.nih.gov/pubmed/20649590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00700.x
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