Engineering a Single Chain Fv Antibody to αvβ6 Integrin using the Specificity-Determining Loop of a Foot-and-Mouth Disease Virus

The αvβ6 integrin is a promising target for cancer therapy. Its expression is up-regulated de novo on many types of carcinoma where it may activate transforming growth factor-β1 and transforming growth factor-β3, interact with the specific extracellular matrix proteins and promote migration and inva...

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Autores principales: Kogelberg, Heide, Tolner, Berend, Thomas, Gareth J., Di Cara, Danielle, Minogue, Shane, Ramesh, Bala, Sodha, Serena, Marsh, Dan, Lowdell, Mark W., Meyer, Tim, Begent, Richard H.J., Hart, Ian, Marshall, John F, Chester, Kerry
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958364/
https://ncbi.nlm.nih.gov/pubmed/18656482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.07.013
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