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VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis.

The destruction of articular cartilage in immune inflammatory arthritic disease involves the proteolytic degradation of its extracellular matrix. The role of activated matrix metalloproteinases (MMPs) in the chondrodestructive process was studied by identifying a selective cleavage product of aggrec...

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Sparad:
I publikationen:J Clin Invest
Huvudupphov: Singer, I I, Kawka, D W, Bayne, E K, Donatelli, S A, Weidner, J R, Williams, H R, Ayala, J M, Mumford, R A, Lark, M W, Glant, T T
Materialtyp: Artigo
Språk:Inglês
Utgiven: American Society for Clinical Investigation 1995
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295822/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7537757/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117907
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