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Group X Secretory Phospholipase A(2) Negatively Regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages
OBJECTIVES: Group X secretory phospholipase A(2) (GX sPLA(2)) potently hydrolyzes plasma membranes to generate lysophospholipids and free fatty acids and has been implicated in inflammatory diseases including atherosclerosis. Here we identify a novel role for GX sPLA(2) in modulating ABCA1 and ABCG1...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2958102/ https://ncbi.nlm.nih.gov/pubmed/20844270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.210237 |
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