Evaluation of Computational Docking to Identify Pregnane X Receptor Agonists in the ToxCast Database

BACKGROUND: The pregnane X receptor (PXR) is a key transcriptional regulator of many genes [e.g., cytochrome P450s (CYP2C9, CYP3A4, CYP2B6), MDR1] involved in xenobiotic metabolism and excretion. OBJECTIVES: As part of an evaluation of different approaches to predict compound affinity for nuclear ho...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Kortagere, Sandhya, Krasowski, Matthew D., Reschly, Erica J., Venkatesh, Madhukumar, Mani, Sridhar, Ekins, Sean
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Institute of Environmental Health Sciences 2010
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957921/
https://ncbi.nlm.nih.gov/pubmed/20558333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1001930
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items