Effects of alpha-thalassemia and sickle polymerization tendency on the urine-concentrating defect of individuals with sickle cell trait.

A defect in urine concentrating ability occurs in individuals with sickle cell trait (HbAS). This may result from intracellular polymerization of sickle hemoglobin (HbS) in erythrocytes, leading to microvascular occlusion, in the vasa recta of the renal medulla. To test the hypothesis that the sever...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Gupta, A K, Kirchner, K A, Nicholson, R, Adams, J G, Schechter, A N, Noguchi, C T, Steinberg, M H
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1991
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295777/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1752955/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115521
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