Effects of alpha-thalassemia and sickle polymerization tendency on the urine-concentrating defect of individuals with sickle cell trait.

A defect in urine concentrating ability occurs in individuals with sickle cell trait (HbAS). This may result from intracellular polymerization of sickle hemoglobin (HbS) in erythrocytes, leading to microvascular occlusion, in the vasa recta of the renal medulla. To test the hypothesis that the sever...

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Bibliographic Details
Main Authors: Gupta, A K, Kirchner, K A, Nicholson, R, Adams, J G, Schechter, A N, Noguchi, C T, Steinberg, M H
Format: Artigo
Language:Inglês
Published: 1991
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC295777/
https://ncbi.nlm.nih.gov/pubmed/1752955
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