Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase

Cyclin D1 elicits transcriptional effects through inactivation of the retinoblastoma protein and direct association with transcriptional regulators. The current work reveals a molecular relationship between cyclin D1/CDK4 kinase and protein arginine methyltransferase 5 (PRMT5), an enzyme associated...

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Bibliografski detalji
Glavni autori: Aggarwal, Priya, Vaites, Laura Pontano, Kim, Jong Kyong, Mellert, Hestia, Gurung, Buddha, Nakagawa, Hiroshi, Herlyn, Meenhard, Hua, Xianxin, Rustgi, Anil K., McMahon, Steven B., Diehl, J. Alan
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957477/
https://ncbi.nlm.nih.gov/pubmed/20951943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.08.012
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