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Speeding through cell cycle roadblocks: Nuclear cyclin D1-dependent kinase and neoplastic transformation
Mitogenic induction of cyclin D1, the allosteric regulator of CDK4/6, is a key regulatory event contributing to G1 phase progression. Following the G1/S transition, cyclin D1 activation is antagonized by GSK3β-dependent threonine-286 (Thr-286) phosphorylation, triggering nuclear export and subsequen...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2543001/ https://ncbi.nlm.nih.gov/pubmed/18764945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1747-1028-3-12 |
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