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Speeding through cell cycle roadblocks: Nuclear cyclin D1-dependent kinase and neoplastic transformation

Mitogenic induction of cyclin D1, the allosteric regulator of CDK4/6, is a key regulatory event contributing to G1 phase progression. Following the G1/S transition, cyclin D1 activation is antagonized by GSK3β-dependent threonine-286 (Thr-286) phosphorylation, triggering nuclear export and subsequen...

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Detalhes bibliográficos
Main Authors: Pontano, Laura L, Diehl, J Alan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2543001/
https://ncbi.nlm.nih.gov/pubmed/18764945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1747-1028-3-12
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