Protein kinase A phosphorylation of tau-serine 214 reorganizes microtubules and disrupts the endothelial cell barrier

Intracellular cAMP is compartmentalized to near membrane domains in endothelium, where it strengthens endothelial cell barrier function. Phosphodiesterase 4D4 (PDE4D4) interacts with the spectrin membrane skeleton and prevents cAMP from accessing microtubules. Expression of a dominant-negative PDE4D...

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Autores principales: Zhu, Bing, Zhang, Li, Creighton, Judy, Alexeyev, Mikhail, Strada, Samuel J., Stevens, Troy
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2010
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957413/
https://ncbi.nlm.nih.gov/pubmed/20639351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00431.2009
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