Molecular basis of subtotal complement C6 deficiency. A carboxy-terminally truncated but functionally active C6.

Individuals with subtotal complement C6 deficiency possess a C6 molecule that is 14% shorter than normal C6 and present in low but detectable concentrations (1-2% of the normal mean). We now show that this dysmorphic C6 is bactericidally active and lacks an epitope that was mapped to the most carbox...

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Pubblicato in:	J Clin Invest
Autori principali:	Würzner, R, Hobart, M J, Fernie, B A, Mewar, D, Potter, P C, Orren, A, Lachmann, P J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295731/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7535801/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117868
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