Molecular basis of subtotal complement C6 deficiency. A carboxy-terminally truncated but functionally active C6.

Individuals with subtotal complement C6 deficiency possess a C6 molecule that is 14% shorter than normal C6 and present in low but detectable concentrations (1-2% of the normal mean). We now show that this dysmorphic C6 is bactericidally active and lacks an epitope that was mapped to the most carbox...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Würzner, R, Hobart, M J, Fernie, B A, Mewar, D, Potter, P C, Orren, A, Lachmann, P J
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1995
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295731/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7535801/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117868
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