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Morpholino oligonucleotides do not participate perfectly in standard Watson-Crick complexes with RNA

RNase P from E. coli will cleave a RNA at a site designated in a complex with an external guide sequence (EGS). The location of the site is determined by the Watson-Crick complementary sequence that can be formed between the RNA and the EGS. Morpholino oligonucleotides (PMOs) that have the same base...

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Detalhes bibliográficos
Main Authors: Xiao, Gaoping, Wesolowski, Donna, Izadjoo, Mina, Altman, Sidney
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957060/
https://ncbi.nlm.nih.gov/pubmed/20817753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2256610
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