Cysteine 723 in the C-linker segment confers oxidative inhibition of hERG1 potassium channels

Excess reactive oxygen species (ROS) play a crucial role under pathophysiological conditions, such as ischaemia/reperfusion and diabetes, potentially contributing to cardiac arrhythmia. hERG1 (KCNH2) potassium channels terminate the cardiac action potential and malfunction can lead to long-QT syndro...

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Bibliografiske detaljer
Main Authors: Kolbe, Katrin, Schönherr, Roland, Gessner, Guido, Sahoo, Nirakar, Hoshi, Toshinori, Heinemann, Stefan H
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2010
Fag:
Molecular and Cellular
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956941/
https://ncbi.nlm.nih.gov/pubmed/20547678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.192468
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