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Mitochondrial DNA Sequence Variation and Haplogroup Distribution in Chinese Patients with LHON and m.14484T>C

BACKGROUND: Leber hereditary optic neuropathy (LHON, MIM 535000) is one of the most common mitochondrial genetic disorders caused by three primary mtDNA mutations (m.3460G>A, m.11778G>A and m. 14484T>C). The clinical expression of LHON is affected by many additional factors, e.g. mtDNA back...

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Библиографические подробности
Главные авторы: Yu, Dandan, Jia, Xiaoyun, Zhang, A-Mei, Li, Shiqiang, Zou, Yang, Zhang, Qingjiong, Yao, Yong-Gang
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956641/
https://ncbi.nlm.nih.gov/pubmed/20976138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013426
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