GPR120 is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-Inflammatory and Insulin Sensitizing Effects

Omega-3 fatty acids (ω-3 FAs), DHA and EPA, exert anti-inflammatory effects, but the mechanisms are poorly understood. Here we show that the G protein-coupled receptor 120 (GPR120) functions as an ω-3 FA receptor/sensor. Stimulation of GPR120 with ω-3 FAs or a chemical agonist causes broad anti-infl...

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Bibliographische Detailangaben
Hauptverfasser: Oh, Da Young, Talukdar, Saswata, Bae, Eun Ju, Imamura, Takeshi, Morinaga, Hidetaka, Fan, WuQiang, Li, Pingping, Lu, Wendell J., Watkins, Steven M., Olefsky, Jerrold M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956412/
https://ncbi.nlm.nih.gov/pubmed/20813258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.07.041
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