Structure of an Ebf1:DNA complex reveals unusual DNA recognition and structural homology with Rel proteins

Early B-cell factor 1 (Ebf1) is a key transcriptional determinant of B-lymphocyte differentiation whose DNA-binding domain has no sequence similarity to other transcription factor families. Here we report the crystal structure of an Ebf1 dimer bound to its palindromic recognition site. The DNA-bindi...

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Hlavní autoři: Treiber, Nora, Treiber, Thomas, Zocher, Georg, Grosschedl, Rudolf
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2010
Témata:
Research Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956205/
https://ncbi.nlm.nih.gov/pubmed/20876732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1976610
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