Effects of 7-O Substitutions on Estrogenic and Antiestrogenic Activities of Daidzein Analogues in MCF-7 Breast Cancer Cells

Daidzein (1) is a natural estrogenic isoflavone. We report here that 1 can be transformed into antiestrogenic ligands by simple alkyl substitutions of the 7-hydroxyl hydrogen. To test the effect of such structural modifications on the hormonal activities of the resulting compounds, a series of daidz...

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Autores principales: Jiang, Quan, Payton-Stewart, Florastina, Elliott, Steven, Driver, Jennifer, Rhodes, Lyndsay V., Zhang, Qiang, Zheng, Shilong, Bhatnagar, Deepak, Boue, Stephen M., Collins-Burow, Bridgette M., Sridhar, Jayalakshmi, Stevens, Cheryl, McLachlan, John A., Wiese, Thomas E., Burow, Matthew E., Wang, Guangdi
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956131/
https://ncbi.nlm.nih.gov/pubmed/20669983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100610w
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