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Evidence for entry of plasma insulin into cerebrospinal fluid through an intermediate compartment in dogs. Quantitative aspects and implications for transport.

To study the route by which plasma insulin enters cerebrospinal fluid (CSF), the kinetics of uptake from plasma into cisternal CSF of both insulin and [14C]inulin were analyzed during intravenous infusion in anesthetized dogs. Four different mathematical models were used: three based on a two-compar...

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Udgivet i:J Clin Invest
Principais autores: Schwartz, M W, Bergman, R N, Kahn, S E, Taborsky, G J, Fisher, L D, Sipols, A J, Woods, S C, Steil, G M, Porte, D
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295596/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1918377/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115431
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