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Mechanism of the ATP-dependent DNA End Resection Machinery from S. cerevisiae
If not properly processed and repaired, DNA double-strand breaks (DSBs) can give rise to deleterious chromosome rearrangements, which could ultimately lead to the tumor phenotype1,2. DSB ends are resected in a 5′ to 3′ fashion in cells, to yield single-stranded DNA for the recruitment of factors cri...
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| 主要な著者: | , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2955862/ https://ncbi.nlm.nih.gov/pubmed/20811460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09318 |
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