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Synergistic chemosensitivity of triple-negative breast cancer cell lines to PARP inhibition, gemcitabine and cisplatin
The basal-like subtype of breast cancer is characterized by a “triple negative” (TN) phenotype (ER-, PR-, HER2/neu-). TN breast cancers share similar gene expression profiles and DNA repair deficiencies with BRCA1-associated breast cancers. BRCA1 mutant cells exhibit sensitivity to gemcitabine, cisp...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2955854/ https://ncbi.nlm.nih.gov/pubmed/20798217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4521 |
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