Dual inhibition of ATR and PARP reverses acquired PARP inhibitor resistance in triple negative breast cancer

Abstract Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) have attracted significant attention in triple negative breast cancer (TNBC) treatment. However, the acquired or de novo PARP inhibitor resistance limits treatment success. Ataxia telangiectasia and Rad3-related (ATR) regulates genome in...

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Hauptverfasser:	Gamze Guney Eskiler, Ayten Haciefendi, Kayhan Ozdemir, Cemil Bilir
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Springer 2025-11-01
Schriftenreihe:	Discover Oncology
Schlagworte:	Triple negative breast cancer cells PARP inhibitors ATR inhibitors PARP inhibitor resistance
Online-Zugang:	https://doi.org/10.1007/s12672-025-03844-x
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