Dual inhibition of ATR and PARP reverses acquired PARP inhibitor resistance in triple negative breast cancer
Abstract Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) have attracted significant attention in triple negative breast cancer (TNBC) treatment. However, the acquired or de novo PARP inhibitor resistance limits treatment success. Ataxia telangiectasia and Rad3-related (ATR) regulates genome in...
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| Автори: | , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Springer
2025-11-01
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| Серія: | Discover Oncology |
| Предмети: | |
| Онлайн доступ: | https://doi.org/10.1007/s12672-025-03844-x |
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