Dual inhibition of ATR and PARP reverses acquired PARP inhibitor resistance in triple negative breast cancer

Abstract Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) have attracted significant attention in triple negative breast cancer (TNBC) treatment. However, the acquired or de novo PARP inhibitor resistance limits treatment success. Ataxia telangiectasia and Rad3-related (ATR) regulates genome in...

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Autores principales:	Gamze Guney Eskiler, Ayten Haciefendi, Kayhan Ozdemir, Cemil Bilir
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Springer 2025-11-01
Colección:	Discover Oncology
Materias:	Triple negative breast cancer cells PARP inhibitors ATR inhibitors PARP inhibitor resistance
Acceso en línea:	https://doi.org/10.1007/s12672-025-03844-x
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