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Inhibition of radiation-induced DNA repair and pro-survival pathways contribute to vorinostat-mediated radiosensitization of pancreatic cancer cells

OBJECTIVE: The intrinsic radioresistance of pancreatic cancer (PaCa) is due to multiple oncogenic signaling pathways. In contrast to combining radiation therapy (RT) with targeted therapeutic agent(s) whose blockade can be circumvented by redundant signaling pathways, we evaluated the combination of...

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Detalhes bibliográficos
Main Authors: Deorukhkar, Amit, Shujun, Shentu, Park, Hee Chul, Diagaradjane, Parmeswaran, Puduvalli, Vinay, Aggarwal, Bharat, Guha, Sushovan, Krishnan, Sunil
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955787/
https://ncbi.nlm.nih.gov/pubmed/20531243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0b013e3181dd63e1
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