Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

Mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) gene, first described in 2004 have now emerged as the most important genetic finding in both autosomal dominant and sporadic Parkinson’s Disease (PD). While a formidable research effort has ensued since the initial gene discovery, little is known...

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Κύριοι συγγραφείς: Melrose, H. L., Dächsel, J. C., Behrouz, B., Lincoln, S. J., Yue, M., Hinkle, K. M., Kent, C., Korvatska, E., Taylor, J. P., Witten, L., Liang, Y-Q, Beevers, J. E., Boules, M., Serna, V., Gaukhman, A., Yu, X., Castanedes-Casey, M., Braithwaite, A. T., Ogholikhan, S., Yu, N., Bass, D., Tyndall, G., Schellenberg, G. D., Dickson, D. W., Janus, C., Farrer, M. J.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2010
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Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955774/
https://ncbi.nlm.nih.gov/pubmed/20659558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2010.07.010
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