Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease

BACKGROUND: Passive immunization with antibodies directed to Aβ decreases brain Aβ/amyloid burden and preserves memory in transgenic mouse models of Alzheimer's disease (AD). This therapeutic strategy is under intense scrutiny in clinical studies, but its application is limited by neuroinflamma...

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Główni autorzy: Minami, S Sakura, Sidahmed, Elkhansa, Aid, Saba, Shimoji, Mika, Niikura, Takako, Mocchetti, Italo, Rebeck, G William, Prendergast, Jay S, Dealwis, Chris, Wetzel, Ronald, Bosetti, Francesca, Matsuoka, Yasuji, Hoe, Hyang-Sook, Turner, R Scott
Format: Artigo
Język:Inglês
Wydane: BioMed Central 2010
Hasła przedmiotowe:
Research
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955708/
https://ncbi.nlm.nih.gov/pubmed/20920207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-7-57
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