Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease

BACKGROUND: Passive immunization with antibodies directed to Aβ decreases brain Aβ/amyloid burden and preserves memory in transgenic mouse models of Alzheimer's disease (AD). This therapeutic strategy is under intense scrutiny in clinical studies, but its application is limited by neuroinflamma...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Minami, S Sakura, Sidahmed, Elkhansa, Aid, Saba, Shimoji, Mika, Niikura, Takako, Mocchetti, Italo, Rebeck, G William, Prendergast, Jay S, Dealwis, Chris, Wetzel, Ronald, Bosetti, Francesca, Matsuoka, Yasuji, Hoe, Hyang-Sook, Turner, R Scott
التنسيق: Artigo
اللغة:Inglês
منشور في: BioMed Central 2010
الموضوعات:
Research
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955708/
https://ncbi.nlm.nih.gov/pubmed/20920207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-7-57
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