Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and Casein Kinase II inhibition as a potential treatment option

BACKGROUND: Myxoid liposarcoma is a relatively common malignant soft tissue tumor, characterized by a (12;16) translocation resulting in a FUS-DDIT3 fusion gene playing a pivotal role in its tumorigenesis. Treatment options in patients with inoperable or metastatic myxoid liposarcoma are relatively...

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Hlavní autoři: Willems, Stefan M, Schrage, Yvonne M, Bruijn, Inge H Briaire-de, Szuhai, Karoly, Hogendoorn, Pancras CW, Bovée, Judith VMG
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955617/
https://ncbi.nlm.nih.gov/pubmed/20863376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-257
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