Pseudomonas and neutrophil products modify transferrin and lactoferrin to create conditions that favor hydroxyl radical formation.

Eitemau Tebyg

• Neutrophil degranulation inhibits potential hydroxyl-radical formation. Relative impact of myeloperoxidase and lactoferrin release on hydroxyl-radical production by iron-supplemented neutrophils assessed by spin-trapping techniques.
  gan: Britigan, B E, et al.
  Cyhoeddwyd: (1989)
• Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Are lactoferrin and transferrin promoters of hydroxyl-radical generation?
  gan: Aruoma, O I, et al.
  Cyhoeddwyd: (1987)
• Possible role of bacterial siderophores in inflammation. Iron bound to the Pseudomonas siderophore pyochelin can function as a hydroxyl radical catalyst.
  gan: Coffman, T J, et al.
  Cyhoeddwyd: (1990)
• Cleavage of Human Transferrin by Porphyromonas gingivalis Gingipains Promotes Growth and Formation of Hydroxyl Radicals
  gan: Goulet, Véronique, et al.
  Cyhoeddwyd: (2004)
• Protease-cleaved iron-transferrin augments oxidant-mediated endothelial cell injury via hydroxyl radical formation.
  gan: Miller, R A, et al.
  Cyhoeddwyd: (1995)