Beta-arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-activated-receptor-2

BACKGROUND: Proteinase-activated-receptor-2 (PAR(2)) is a seven transmembrane receptor that can activate two separate signaling arms: one through Gαq and Ca(2+ )mobilization, and a second through recruitment of β-arrestin scaffolds. In some cases downstream targets of the Gαq/Ca(2+ )signaling arm ar...

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Hlavní autoři: Wang, Ping, Jiang, Yong, Wang, Yinsheng, Shyy, John Y, DeFea, Kathryn A
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955585/
https://ncbi.nlm.nih.gov/pubmed/20858278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-11-36
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